Bionic Biphasic Composite Scaffold with Osteochondrogenic Factors for Regeneration of Full-Thickness Osteochondral Defect
نویسندگان
چکیده
منابع مشابه
Biomimetic biphasic scaffolds for osteochondral defect repair
The osteochondral defects caused by vigorous trauma or physical disease are difficult to be managed. Tissue engineering provides a possible option to regenerate the damaged osteochondral tissues. For osteochondral reconstruction, one intact scaffold should be considered to support the regeneration of both cartilage and subchondral bone. Therefore, the biphasic scaffolds with the mimic structure...
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INTRODUCTION: Osteoarthritis is the leading cause of physical disability among Americans, and tissue engineered osteochondral grafts have emerged as a promising treatment option for this debilitating condition. Currently, the formation of a stable interface between the cartilage and bone portions of the osteochondral graft remains a significant challenge[1]. Articular cartilage integrates with ...
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Intervertebral disc (IVD) degeneration is the major cause of lower back pain, while the currently available treatments are symptomatic rather than curative. Tissue engineering is a powerful therapeutic strategy that can restore the normal biomechanical motion of the human spine. The ability of a biphasic elastic scaffold to structurally and elastically simulate the annulus fibrosus (AF) tissue ...
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BACKGROUND Collagens of marine origin are applied increasingly as alternatives to mammalian collagens in tissue engineering. The aim of the present study was to develop a biphasic scaffold from exclusively marine collagens supporting both osteogenic and chondrogenic differentiation and to find a suitable setup for in vitro chondrogenic and osteogenic differentiation of human mesenchymal stroma ...
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Isolated cartilage defects can lead to significant pain and disability, prompting the development of a number of options for restorative treatment. Each method has advantages and limitations, and no single technique has gained widespread use. We present a technique for implantation of a cryopreserved osteochondral allograft (Cartiform) for the treatment of full-thickness cartilage defects. Cart...
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ژورنال
عنوان ژورنال: Social Science Research Network
سال: 2021
ISSN: ['1556-5068']
DOI: https://doi.org/10.2139/ssrn.3961277